Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.

@article{Xu2016RegulationOD,
  title={Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.},
  author={Ming Xu and Qiufang Zhang and P L Li and Thaison Nguyen and Xiang Li and Yang Zhang},
  journal={Frontiers in bioscience},
  year={2016},
  volume={21},
  pages={696-706}
}
Acid sphingomyelinase (ASM; gene symbol Smpd1) has been shown to play a crucial role in autophagy maturation by controlling lysosomal fusion with autophagosomes in coronary arterial smooth muscle cells (CASMCs). However, the underlying molecular mechanism by which ASM controls autophagolysosomal fusion remains unknown. In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1… CONTINUE READING