Regulation of drug transporter gene expression by nuclear receptors.

@article{Staudinger2003RegulationOD,
  title={Regulation of drug transporter gene expression by nuclear receptors.},
  author={Jeff L. Staudinger and Ajay Madan and Kathleen M Carol and Andrew Parkinson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 5},
  pages={523-7}
}
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are key regulators of xenobiotic-inducible cytochrome P450 gene expression. Whereas much is known about their role in regulating drug metabolism, little is known regarding their role in regulating drug transport in vivo. Wild-type mice and mice lacking PXR (PXR-KO) were used to examine the inducible expression of two drug transporter genes, Oatp2 (Slc21a5) and Mrp3 (Abcc3), in liver following treatment with selective PXR and… CONTINUE READING