Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.

  title={Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.},
  author={Antonia H. Tolson and Hongbing Wang},
  journal={Advanced drug delivery reviews},
  volume={62 13},
Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition and detoxification of numerous foreign and endogenous chemicals. To accommodate chemical challenges, the expression of many DMEs and transporters is up-regulated by a group of ligand-activated transcription factors namely nuclear receptors (NRs). The importance of NRs in xenobiotic metabolism and clearance is best exemplified by the most promiscuous xenobiotic receptors: pregnane X receptor (PXR, NR1I2) and… CONTINUE READING
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