Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.

@article{Morgan2008RegulationOD,
  title={Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.},
  author={Edward T Morgan and Kerry B. Goralski and Micheline Piquette-Miller and Kenneth W. Renton and Graham R. Robertson and Madhusudana R. Chaluvadi and Kellie A. Charles and Stephen Clarke and Marina Kacevska and Christopher Liddle and Terrilyn A. Richardson and Rohini Sharma and Christopher J. Sinal},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 2},
  pages={
          205-16
        }
}
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 07 meeting in Washington, DC. The presentations discussed the phenomenology, clinical consequences, and underlying mechanisms of cytochrome P450 and drug transporter regulation by inflammatory and infectious stimuli. Although considerable insights into the links between inflammatory mediators and altered hepatic drug clearance pathways… CONTINUE READING

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