Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.

@article{Han2013RegulationOD,
  title={Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.},
  author={Derick S Han and Lily Dara and Sanda Win and Tin Aung Than and Liyun Yuan and Sadeea Q Abbasi and Zhang-Xu Liu and Neil Kaplowitz},
  journal={Trends in pharmacological sciences},
  year={2013},
  volume={34 4},
  pages={243-53}
}
Drugs that cause liver injury often 'stress' mitochondria and activate signal transduction pathways important in determining cell survival or death. In most cases, hepatocytes adapt to the drug-induced stress by activating adaptive signaling pathways, such as mitochondrial adaptive responses and nuclear factor erythroid 2-related factor 2 (Nrf-2), a transcription factor that upregulates antioxidant defenses. Owing to adaptation, drugs alone rarely cause liver injury, with acetaminophen (APAP… CONTINUE READING