Regulation of dopaminergic transmission and cocaine reward by the Clock gene.

  title={Regulation of dopaminergic transmission and cocaine reward by the Clock gene.},
  author={Colleen A McClung and Kyriaki Sidiropoulou and Martha H Vitaterna and Joseph S Takahashi and Francis J. White and Donald C. Cooper and Eric J Nestler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 26},
Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating the brain's reward circuit. Mice lacking a functional Clock gene display an increase in cocaine reward and in the excitability of dopamine neurons in the midbrain ventral tegmental area, a key brain reward region. These phenotypes are associated with increased expression and phosphorylation of tyrosine… CONTINUE READING
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Mouse Brain in Stereotaxic Coordinates (Academic, San Diego)

  • F. J. White
  • Annu. Rev. Neurosci
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