Regulation of dog thyroid epithelial cell cycle by forskolin, an adenylate cyclase activator.

@article{Roger1987RegulationOD,
  title={Regulation of dog thyroid epithelial cell cycle by forskolin, an adenylate cyclase activator.},
  author={Pierre P Roger and Patricia Servais and Jacques E. Dumont},
  journal={Experimental cell research},
  year={1987},
  volume={172 2},
  pages={282-92}
}
Dog thyroid epithelial follicular cells in primary culture are quiescent in an insulin-supplemented serum-free medium. They are induced, after a 16- to 20-h prereplicative phase, to synthesize DNA upon stimulation by forskolin, a general adenylate cyclase activator that mimics all the effects of thyrotropin in these cells. The characteristics of adenylate cyclase activation by forskolin make this drug a convenient tool to enhance cellular cyclic AMP levels for well-defined periods of the cell… CONTINUE READING