Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch

@article{Kahle2005RegulationOD,
  title={Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch},
  author={Kristopher Thomas Kahle and Frederick H Wilson and Richard P. Lifton},
  journal={Trends in Endocrinology & Metabolism},
  year={2005},
  volume={16},
  pages={98-103}
}
Key components of complex physiological regulatory pathways can be uncovered through the molecular-genetic study of rare, inherited diseases. WNK kinases are a recently discovered class of serine-threonine kinases that are distinctive because of the substitution of cysteine for lysine in subdomain II of the catalytic domain. Mutations in PRKWNK1 and PRKWNK4, which encode WNK1 and WNK4, result in an inherited syndrome of hypertension and hyperkalemia. Recent physiological work has revealed that… CONTINUE READING
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