Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non‐haem iron

@article{Johnson2005RegulationOD,
  title={Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non‐haem iron},
  author={Deborah Marie Johnson and Sachie Yamaji and Jason Tennant and Surjit Kaila S. Srai and Paul A Sharp},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
A number of regulatory factors including dietary iron levels can dramatically alter the expression of the intestinal iron transporter DMT1. Here we show that Caco‐2 cells exposed to iron for 4 h exhibited a significant decrease in plasma membrane DMT1 protein, though total cellular DMT1 levels were unaltered. Following biotinylation of cell surface proteins, there was a significant increase in intracellular biotin‐labelled DMT1 in iron‐exposed cells. Furthermore, iron‐treatment increased levels… Expand
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