Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non‐haem iron

@article{Johnson2005RegulationOD,
  title={Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non‐haem iron},
  author={Deborah Marie Johnson and Sachie Yamaji and Jason Tennant and Surjit Kaila S. Srai and Paul A Sharp},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells
TLDR
Data suggest that, in addition to the effects of cellular iron status on the expression of iron transporter genes, different modes and direction of iron supply to enterocytes can elicit distinct functional effects on iron transport.
Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells.
TLDR
The data suggest that iron uptake induces the production of ROS, which modify DMT1 endocytic cycling, thus changing the iron transport activity at the apical membrane.
In Vitro Study to determine the effect of zinc on non-hemeiron absorption
TLDR
The evidence from in vitro studies show that zinc suppressed iron uptake by Caco-2 cells and this phenomenon could be reversed by the presence of ascorbic acid in the growth media.
Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro
TLDR
This study highlights a novel mechanism for the regulation of iron bioavailability by dietary polyphenols and suggests diets rich in polyphenol might be beneficial for patients groups at risk of iron loading by limiting the rate of intestinal iron absorption.
Molecular mechanisms involved in intestinal iron absorption.
TLDR
This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation and aims to provide a clearer picture regarding the transcellular flux of iron and its regulation by dietary and humoral factors.
High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves.
TLDR
Feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents.
Proteins of Iron Homeostasis
TLDR
While the body levels of other dietary metals can be regulated by excretion in the feces and urine, humans do not possess the capacity to remove excess iron from the body, so a number of proteins have evolved which tightly regulate mammalian iron homeostasis.
Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure.
TLDR
Results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.
Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
TLDR
The fact that macrophages respond more acutely to a hepcidin challenge is fully consistent with their central role in maintaining body iron homeostasis as well as the fact that the duodenum appears to be less sensitive to this initial rise in hePCidin levels.
Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells
TLDR
The data suggest that miR-Let-7d participates in the finely tuned regulation of iron metabolism by targeting DMT1-IRE isoform in erythroid cells.
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  • Nadia Hubert, M. Hentze
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
TLDR
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TLDR
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TLDR
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