Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

@article{Lee2000RegulationOD,
  title={Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity},
  author={Hey-Kyoung Lee and Michaela Barbarosie and Kimihiko Kameyama and Mark F. Bear and Richard L. Huganir},
  journal={Nature},
  year={2000},
  volume={405},
  pages={955-959}
}
Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for information storage in the brain. LTP and LTD may be mediated by the modulation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazloe proprionic acid) receptor phosphorylation. Here we show that LTP and LTD reversibly modify the phosphorylation of the AMPA receptor GluR1 subunit. However, contrary to the hypothesis… CONTINUE READING
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