Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

  title={Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity},
  author={H. Lee and M. Barbarosie and K. Kameyama and M. Bear and R. Huganir},
  • H. Lee, M. Barbarosie, +2 authors R. Huganir
  • Published 2000
  • Biology, Medicine
  • Nature
  • Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for information storage in the brain. LTP and LTD may be mediated by the modulation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazloe proprionic acid) receptor phosphorylation. Here we show that LTP and LTD reversibly modify the phosphorylation of the AMPA receptor GluR1 subunit. However, contrary to the hypothesis… CONTINUE READING
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