Regulation of differentiation of vascular smooth muscle cells.

  title={Regulation of differentiation of vascular smooth muscle cells.},
  author={Gary K. Owens},
  journal={Physiological reviews},
  volume={75 3},
  • G. Owens
  • Published 1 July 1995
  • Biology
  • Physiological reviews
The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose principal function is contraction. The fully differentiated or mature SMC proliferates at an extremely low rate and is a cell almost completely geared for contraction. It expresses a unique repertoire of contractile proteins, ion channels, and signaling molecules that are required for its contractile function and that when taken in aggregate clearly distinguish it from any other cell type. During… 

Role of mechanical strain in regulation of differentiation of vascular smooth muscle cells.

Of particular significance, phenotypic alterations in intimal SMCs within atherosclerotic lesions include not only enhanced growth responsiveness but also altered lipid metabolism and increased matrix production, which are likely to play a major role in the development and/or progression of atherosclerosis.

Molecular control of vascular smooth muscle cell differentiation.

  • G. Owens
  • Biology
    Acta physiologica Scandinavica
  • 1998
Key questions include determination of mechanisms that control the coordinate expression of genes required for the differentiated function of the smooth muscle cell, and determination as to how these regulatory processes are influenced by local environmental cues known to be important to control of smooth muscle differentiation.

Regulation of differentiation/maturation in vascular smooth muscle cells by hormones and growth factors.

The effects of growth factors, growth inhibitors, and other extrinsic factors on differentiation/maturation ofSMC are reviewed, with a particular emphasis on consideration of factors that may contribute to abnormal control of SMC differentiation in vascular disease.

Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins.

The present study determined, using Western analysis, double-label immunofluorescence and confocal microscopy, whether changes in phenotypic expression of rabbit aortic SMC in culture could be correlated with alterations in expression and distribution of structural proteins.

Origin and differentiation of vascular smooth muscle cells

The origin and differentiation of SMCs from stem/progenitor cells during cardiovascular development and in the adult are reviewed, highlighting the environmental cues and signalling pathways that control phenotypic modulation within the vasculature.

Vascular smooth muscle cells: isolation, culture, and characterization.

This chapter discusses in detail the explant method for isolation of VSMC and will compare it to the enzymatic digestion method and briefly describe methods for characterizing the resulting cells.

Epigenetic regulation of smooth muscle cell plasticity.

c-Myb Dependent Smooth Muscle Cell Differentiation from Mouse Embryonic Stem Cells

This thesis aimed to implicate the c-Myb transcription factor in the process of SMC differentiation, using the embryoid body model system to clarify the molecular pathways and extrinsic factors that promote or obstruct SMC lineage specification and maturation to the contractile phenotype.

The Phenotypic Responses of Vascular Smooth Muscle Cells Exposed to Mechanical Cues

Recent literature on how the mechanical forces and derived biochemical signals have been shown to modulate the vascular SMC phenotype are reviewed and discussed and new perspectives about their importance are provided.