Regulation of differentiation of vascular smooth muscle cells.

@article{Owens1995RegulationOD,
  title={Regulation of differentiation of vascular smooth muscle cells.},
  author={Gary K. Owens},
  journal={Physiological reviews},
  year={1995},
  volume={75 3},
  pages={
          487-517
        }
}
  • G. Owens
  • Published 1 July 1995
  • Biology, Medicine
  • Physiological reviews
The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose principal function is contraction. The fully differentiated or mature SMC proliferates at an extremely low rate and is a cell almost completely geared for contraction. It expresses a unique repertoire of contractile proteins, ion channels, and signaling molecules that are required for its contractile function and that when taken in aggregate clearly distinguish it from any other cell type. During… Expand
Role of mechanical strain in regulation of differentiation of vascular smooth muscle cells.
  • G. Owens
  • Biology, Medicine
  • Circulation research
  • 1996
TLDR
Of particular significance, phenotypic alterations in intimal SMCs within atherosclerotic lesions include not only enhanced growth responsiveness but also altered lipid metabolism and increased matrix production, which are likely to play a major role in the development and/or progression of atherosclerosis. Expand
Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normalExpand
Molecular control of vascular smooth muscle cell differentiation.
  • G. Owens
  • Biology, Medicine
  • Acta physiologica Scandinavica
  • 1998
TLDR
Key questions include determination of mechanisms that control the coordinate expression of genes required for the differentiated function of the smooth muscle cell, and determination as to how these regulatory processes are influenced by local environmental cues known to be important to control of smooth muscle differentiation. Expand
Regulation of differentiation/maturation in vascular smooth muscle cells by hormones and growth factors.
TLDR
The effects of growth factors, growth inhibitors, and other extrinsic factors on differentiation/maturation ofSMC are reviewed, with a particular emphasis on consideration of factors that may contribute to abnormal control of SMC differentiation in vascular disease. Expand
Differentiated properties and proliferation of arterial smooth muscle cells in culture.
  • J. Thyberg
  • Biology, Medicine
  • International review of cytology
  • 1996
TLDR
The cell culture technique has contributed substantially to knowledge of smooth muscle differentiation and growth and has been crucial in exploring the role of these cells in vascular disease and developing new therapeutic strategies to cope with major causes of human death and disability. Expand
Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins.
TLDR
The present study determined, using Western analysis, double-label immunofluorescence and confocal microscopy, whether changes in phenotypic expression of rabbit aortic SMC in culture could be correlated with alterations in expression and distribution of structural proteins. Expand
Regulation of Vascular Smooth Muscle Differentiation and Cell Cycle
TLDR
Extracellular matrix may play a key role in maintaining homeostasis of the vasculature, whereby integrins provide a sensing mechanism utilized by VSMCs to monitor tissue integrity within the artery. Expand
Vascular smooth muscle cells: isolation, culture, and characterization.
TLDR
This chapter discusses in detail the explant method for isolation of VSMC and will compare it to the enzymatic digestion method and briefly describe methods for characterizing the resulting cells. Expand
Origin and differentiation of vascular smooth muscle cells
TLDR
The origin and differentiation of SMCs from stem/progenitor cells during cardiovascular development and in the adult are reviewed, highlighting the environmental cues and signalling pathways that control phenotypic modulation within the vasculature. Expand
Epigenetic regulation of smooth muscle cell plasticity.
TLDR
The epigenetic regulation of SMC is summarized, highlighting the role of histone modification, DNA methylation, and the most recent identification of a DNA demethylation pathway in SMC that is pivotal in the regulation of the SMC phenotypic state. Expand
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