Regulation of differentiation by HBP1, a target of the retinoblastoma protein.

@article{Shih1998RegulationOD,
  title={Regulation of differentiation by HBP1, a target of the retinoblastoma protein.},
  author={Heather H. Shih and Sergei G. Tevosian and Amy Shun Wah Yee},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 8},
  pages={
          4732-43
        }
}
Differentiation is a coordinated process of irreversible cell cycle exit and tissue-specific gene expression. To probe the functions of the retinoblastoma protein (RB) family in cell differentiation, we isolated HBP1 as a specific target of RB and p130. Our previous work showed that HBP1 was a transcriptional repressor and a cell cycle inhibitor. The induction of HBP1, RB, and p130 upon differentiation in the muscle C2C12 cells suggested a coordinated role. Here we report that the expression of… CONTINUE READING
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