Regulation of different human NFAT isoforms by neuronal activity.

  title={Regulation of different human NFAT isoforms by neuronal activity.},
  author={Hanna Vihma and Mirjam Luhakooder and Priit Pruunsild and T{\~o}nis Timmusk},
  journal={Journal of neurochemistry},
  volume={137 3},
Nuclear factor of activated T-cells (NFAT) is a family of transcription factors comprising four calcium-regulated members: NFATc1, NFATc2, NFATc3, and NFATc4. Upon activation by the calcium-dependent phosphatase calcineurin (CaN), NFATs translocate from cytosol to the nucleus and regulate their target genes, which in the nervous system are involved in axon growth, synaptic plasticity, and neuronal survival. We have shown previously that there are a number of different splice variants of NFAT… CONTINUE READING
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