Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.

@article{Choi2014RegulationOD,
  title={Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.},
  author={Kwangman Choi and Hyeongki Kim and Hyunju Kang and So-Young Lee and Sang Yup Lee and Sung Hoon Back and Seo Hyun Lee and Moon Sun Kim and Jeong Eun Lee and Ju Young Park and Jiye Kim and Sunhong Kim and Jae-Hyung Song and Yura Choi and Suui Lee and Hyun-Jun Lee and Jong Heon Kim and Sungchan Cho},
  journal={The FEBS journal},
  year={2014},
  volume={281 13},
  pages={3048-60}
}
Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by diacylglycerol acyltransferase (DGAT) in the endoplasmic reticulum (ER). DGAT2, one of the two DGAT enzymes, is barely detectable in cells, even though its mRNA transcripts are maintained at considerable levels. However, little is known about how DGAT2 expression is altered by protein stability. DGAT2 was highly unstable in cells and was rapidly degraded by proteasomes in an ubiquitin-dependent… CONTINUE READING
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