Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity.

@article{PartidaSanchez2004RegulationOD,
  title={Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity.},
  author={Santiago Partida-Sanchez and Stephen P Goodrich and Kim L. Kusser and Norman J. Oppenheimer and Troy D. Randall and Frances E. Lund},
  journal={Immunity},
  year={2004},
  volume={20 3},
  pages={
          279-91
        }
}
Mice lacking CD38, an ectoenzyme that generates the calcium-mobilizing metabolite cADPR, make reduced T cell-dependent antibody responses. Despite the predicted role for CD38 in B cell activation, we find that CD38 regulates the migration of dendritic cell (DC) precursors from the blood to peripheral sites and controls the migration of mature DCs from sites of inflammation to lymph nodes. Thus, T cells are inefficiently primed in Cd38(-/-) mice, leading to poor humoral immune responses. We also… CONTINUE READING
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