Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

  title={Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.},
  author={Gabrielle Faure-Andr{\'e} and Pablo Vargas and M I Yuseff and M{\'e}lina L. Heuz{\'e} and Jheimmy Diaz and Danielle Lankar and Veronica Steri and J{\'e}r{\'e}my Manry and St{\'e}phanie Hugues and Fulvia Vascotto and J{\'e}r{\^o}me Boulanger and Graça Raposo and Maria-Rosa Bono and Mario Rosemblatt and Matthieu Piel and Ana-Mar{\'i}a Lennon-Dum{\'e}nil},
  volume={322 5908},
Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that… CONTINUE READING
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