Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

@article{FaureAndr2008RegulationOD,
  title={Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.},
  author={Gabrielle Faure-Andr{\'e} and Pablo Vargas and M I Yuseff and M{\'e}lina L. Heuz{\'e} and Jheimmy Diaz and Danielle Lankar and Veronica Steri and J{\'e}r{\'e}my Manry and St{\'e}phanie Hugues and Fulvia Vascotto and J{\'e}r{\^o}me Boulanger and Graça Raposo and Maria-Rosa Bono and Mario Rosemblatt and Matthieu Piel and Ana-Mar{\'i}a Lennon-Dum{\'e}nil},
  journal={Science},
  year={2008},
  volume={322 5908},
  pages={1705-10}
}
Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that… CONTINUE READING
96 Citations
6 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

References

Publications referenced by this paper.
Showing 1-6 of 6 references

J Cell Biol

  • F Vascotto
  • J Cell Biol
  • 2007

Cell Motil Cytoskeleton

  • M Thery, A Pepin, E Dressaire, Y Chen, M Bornens
  • Cell Motil Cytoskeleton
  • 2006

IEEE Trans Image Process

  • H Foroosh, J B Zerubia, M Berthod
  • IEEE Trans Image Process
  • 2002

J Exp Med

  • D Lankar
  • J Exp Med
  • 2002

Annu Rev Biomed Eng

  • G M Whitesides, E Ostuni, S Takayama, X Jiang, D E Ingber
  • Annu Rev Biomed Eng
  • 2001

Journal of Visual Communication and Image Representation

  • J M Odobez, P Bouthemy
  • Journal of Visual Communication and Image…
  • 1995

Similar Papers

Loading similar papers…