Regulation of dendritic cell function through Toll-like receptors.

  title={Regulation of dendritic cell function through Toll-like receptors.},
  author={Tsuneyasu Kaisho and Shizuo Akira},
  journal={Current molecular medicine},
  volume={3 4},
Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten… CONTINUE READING