Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation.

@article{Pan2004RegulationOD,
  title={Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation.},
  author={P Y Pan and Peidi Gu and Qingsheng Li and Dongping Xu and Kaare Weber and Shu-hsia Chen},
  journal={Journal of immunology},
  year={2004},
  volume={172 8},
  pages={4779-89}
}
The interactions between NK cells and dendritic cells (DCs) have been previously demonstrated in vitro. In this report, the in vivo cross-regulation between NK cells and DCs was studied in tumor-bearing mice treated with adenoviral vector expressing IL-12 and agonistic anti-4-1BB Abs. NK cells are essential for both tumor rejection and CTL development in the combination therapy (IL-12 plus anti-4-1BB). The numbers and functional activities of both NK cells and DCs in tumor-infiltrating… CONTINUE READING

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