Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells.

@article{Leung1998RegulationOD,
  title={Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells.},
  author={Lai K Leung and Loi H Do and Thomas T. Y. Wang},
  journal={Cancer letters},
  year={1998},
  volume={124 1},
  pages={47-52}
}
In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cells with 17beta-estradiol resulted in inhibition of the time-dependent increases in Bak mRNA and protein. The effects of estradiol appeared to be via estrogen receptor as treatment… CONTINUE READING

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