Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins.

Abstract

The experimental evidence is convincing that cytosolic guanylate cyclase is a hemoprotein containing stoichiometric amounts of heme, which functions as a prosthetic group for enzyme activation by NO. Nearly all of the studies described in this chapter were conducted before we began to appreciate in 1986 that mammalian vascular endothelial cells could… (More)

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@article{Ignarro1994RegulationOC, title={Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins.}, author={Louis Joseph Ignarro}, journal={Advances in pharmacology}, year={1994}, volume={26}, pages={35-65} }