Regulation of cytosolic free calcium in isolated rat osteoclasts by calcitonin.

  title={Regulation of cytosolic free calcium in isolated rat osteoclasts by calcitonin.},
  author={Baljit S. Moonga and A. S. M. Towhidul Alam and Peter J. R. Bevis and F Avaldi and Renato Soncini and Christopher L.-H. Huang and M Shoaib Zaidi},
  journal={The Journal of endocrinology},
  volume={132 2},
It is now established that calcium is a second messenger mediating the action of calcitonin on the osteoclast. We have demonstrated that an increase in the concentration of intracellular free calcium ([Ca2+]i) is associated with (and possibly mediates) the functional effects of calcitonin, including an acute reduction of cell spread area (the R effect) and, in the longer term, a reduction in enzyme release. The present study addresses questions relating to mechanisms of calcitonin action on… CONTINUE READING

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