Regulation of cytoskeletal proteins by thyroid hormone during neuronal maturation and differentiation.

Abstract

Primary cultures of neurons from 16- to 17-day-old embryonic rat cerebra were maintained for 3 weeks in thyroid hormone deficient (THdef) and thyroid hormone supplemented (THsup) media to investigate how TH regulates the cytoskeletal (CSK) proteins during neuronal differentiation and maturation. Two distinct phases of regulation of triton-insoluble CSK… (More)

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