Regulation of cytoplasmic mRNA decay

@article{Schoenberg2012RegulationOC,
  title={Regulation of cytoplasmic mRNA decay},
  author={Daniel R Schoenberg and Lynne E Maquat},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={246-259}
}
Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation influences mRNA decay and the ribonucleases that catalyse decay. Now, current studies have begun to elucidate how the decay process is regulated… CONTINUE READING
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