Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

@article{Charles1999RegulationOC,
  title={Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.},
  author={Peter J. Charles and Michael J. Elliott and Della Davis and Alison Potter and Joachim. R. Kalden and Christian E. Antoni and Ferdinand C. Breedveld and Josef S Smolen and Gabriele Eberl and Kim deWoody and Marc Feldmann and Ravinder N. Maini},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1521-8}
}
Treatment with a chimeric mAb to TNF-alpha has been shown to suppress inflammation and improve patient well-being in rheumatoid arthritis (RA), but the mechanisms of action of such treatment have not been fully explored. Here we show that in vivo administration of anti-TNF-alpha Ab, using a longitudinal analysis, results in the rapid down-regulation of a spectrum of cytokines, cytokine inhibitors, and acute-phase proteins. Marked diurnal variation in the serum levels of some of these were… CONTINUE READING
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