Regulation of cytokine expression by human blood basophils.

  title={Regulation of cytokine expression by human blood basophils.},
  author={Clemens Andreas Dahinden and Silvia Rihs and B Ochsensberger},
  journal={International archives of allergy and immunology},
  volume={113 1-3},
IL-4 and IL-13 are key immunoregulatory cytokines because of their ability to induce and amplify Th2-type immune responses and by promoting IgE formation. The basophil is a particularly prominent source of IL-4/IL-13, which are rapidly produced upon Fc epsilonRI cross-linking. Cytokine expression by basophils is unique and distinct from other cell types, since: (1) Basophils are the only cell type constitutively expressing IL-4 and IL-13 mRNA. IL-4/IL-13 message and protein are expressed in a… CONTINUE READING


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