Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury.

@article{Bhakta2008RegulationOC,
  title={Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury.},
  author={Kushal Y Bhakta and Weiwu Jiang and Xanthi I. Couroucli and Inayat Saleem Fazili and Kathirvel Muthiah and Bhagavatula Moorthy},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={233 2},
  pages={169-78}
}
Supplemental oxygen, used to treat pulmonary insufficiency in newborns, contributes to the development of bronchopulmonary dysplasia (BPD). Cytochrome P4501A enzymes are induced by hyperoxia in animal models, but their role in human systems is unknown. Here we investigated the molecular mechanisms of induction of CYP1A1 by hyperoxia in human lung cell lines. Three human lung cell lines were exposed to hyperoxia (95% O2) for 0-72 h, and CYP1A1 activities, apoprotein contents, and mRNA levels… CONTINUE READING

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