Regulation of cyclooxygenase activity by metamizol.

@article{Campos1999RegulationOC,
  title={Regulation of cyclooxygenase activity by metamizol.},
  author={Cristina Campos and R de Gregorio and Raquel Garc{\'i}a-Nieto and Federico Gago and Pedro Ortiz and Susana Alemany},
  journal={European journal of pharmacology},
  year={1999},
  volume={378 3},
  pages={339-47}
}
The ability of metamizol to inhibit cyclooxygenase-1 and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-1 and cyclooxygenase-2 with an IC50 of about 150 microg/ml. A similar IC50 value for cyclooxygenase-2 was obtained in lipopolysaccharide-activated broken murine macrophages. Consistent with these findings, molecular models of the complexes between cyclooxygenase-1 or cyclooxygenase-2 with 4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

AutoDock: automated docking of flexible ligands to receptors, version 2.4

  • G. M. Morris, D. S. Goodsell, R. Huey, A. J. Olson
  • The Scripps Research Institute,
  • 1996
Highly Influential
5 Excerpts

Automated docking

  • R. Garcıa-Nieto, C. Perez, F. Gago
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…