Regulation of cyclooxygenase activity by metamizol.

  title={Regulation of cyclooxygenase activity by metamizol.},
  author={Cristina Campos and R de Gregorio and Raquel Garc{\'i}a-Nieto and Federico Gago and Pedro Ortiz and Susana Alemany},
  journal={European journal of pharmacology},
  volume={378 3},
The ability of metamizol to inhibit cyclooxygenase-1 and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-1 and cyclooxygenase-2 with an IC50 of about 150 microg/ml. A similar IC50 value for cyclooxygenase-2 was obtained in lipopolysaccharide-activated broken murine macrophages. Consistent with these findings, molecular models of the complexes between cyclooxygenase-1 or cyclooxygenase-2 with 4… CONTINUE READING


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