Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.

@article{Chiang2012RegulationOC,
  title={Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.},
  author={Karen Chiang and T Sung and Andrew P. Rice},
  journal={Journal of virology},
  year={2012},
  volume={86 6},
  pages={3244-52}
}
The replication of integrated human immunodeficiency virus type 1 (HIV-1) is dependent on the cellular cofactor cyclin T1, which binds the viral Tat protein and activates the RNA polymerase II transcription of the integrated provirus. The activation of resting CD4(+) T cells upregulates cyclin T1 protein levels independently of an increase in cyclin T1 mRNA… CONTINUE READING