Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.

@article{Fox2008RegulationOC,
  title={Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.},
  author={Keith E Fox and Lillester A Colton and Paul F. Erickson and Jacob E. Friedman and Hyuk Chol Cha and Pernille Keller and Ormond A Macdougald and Dwight J. Klemm},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 50},
  pages={35096-105}
}
Cyclin D1 expression is elevated and Wnt10b is repressed by cAMP during the first few hours of adipogenesis. cAMP-responsive element-binding protein (CREB) is a primary target for cAMP signaling, and we have shown that activation of CREB promotes adipogenesis and adipocyte survival. Here we tested the impact of CREB on expression of cyclin D1 and wingless-related mouse mammary tumor virus integration site 10b (Wnt10b) in 3T3-L1 cells. Forced depletion of CREB blocked Bt(2)cAMP-stimulated cyclin… CONTINUE READING