Regulation of cyclin D-dependent kinase activity in rat liver regeneration.

  title={Regulation of cyclin D-dependent kinase activity in rat liver regeneration.},
  author={Akira Kato and Shuichi Ota and Hiromichi Bamba and Raymond Wong and Eiji Ohmura and Yoichi Imai and Fumio Matsuzaki},
  journal={Biochemical and biophysical research communications},
  volume={245 1},
The regulation of cyclin D-dependent kinase activity in tissue regeneration in vivo has not been fully described. In young adult rat liver after 70% partial hepatectomy, the association of cyclin D1 with cdk4 was significantly promoted during G1 phase and was maximal at 18 hr, corresponding mainly to late G1. Cyclin D1-dependent kinase activity also strongly increased during G1 phase. The timing of the induction of cyclin D1 / cdk4 complex assembly correlated well with that of cyclin D1… CONTINUE READING

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