Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) results from mutations in tumor suppressor gene Men1, which encodes nuclear protein menin. Menin up-regulates certain cyclin-dependent kinase inhibitors through increasing histone H3 lysine 4 (H3K4) methylation and inhibits G(0)/G(1) to S phase transition. However, little is known as to whether menin controls G(2… (More)
DOI: 10.1074/jbc.M110.106575

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