Regulation of cyclic AMP levels in guinea pig pancreatic ducts and cultured duct epithelial monolayers.

@article{Ondarza1995RegulationOC,
  title={Regulation of cyclic AMP levels in guinea pig pancreatic ducts and cultured duct epithelial monolayers.},
  author={J de Ondarza and Seth R. Hootman},
  journal={Pancreas},
  year={1995},
  volume={11 3},
  pages={261-70}
}
Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cyclic AMP levels in isolated guinea pig main and interlobular pancreatic duct segments and in cultured duct epithelial monolayers. Secretin (0.1 microM) caused a five- to eightfold… CONTINUE READING