Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.

@article{Teli2005RegulationOC,
  title={Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.},
  author={Thalia Teli and Danijela Markovic and Michael Levine and Edward W. Hillhouse and Dimitris Grammatopoulos},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 2},
  pages={474-90}
}
Attenuation of CRH receptor type 1 (CRH-R1) signaling activity might involve desensitization and uncoupling of CRH-R1 from intracellular effectors. We investigated the desensitization of native CRH-R in human myometrial cells from pregnant women and recombinant CRH-R1alpha stably overexpressed in human embryonic kidney (HEK) 293 cells. In both cell types… CONTINUE READING