Regulation of core clock genes in human islets.

  title={Regulation of core clock genes in human islets.},
  author={Jelena A Stamenkovic and Anders H. Olsson and Cecilia L. F. Nagorny and Siri Malmgren and Marloes Dekker-Nitert and Charlotte Ling and Hindrik Mulder},
  journal={Metabolism: clinical and experimental},
  volume={61 7},
Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine whether clock genes could play a pathogenetic role in the disease, we examined messenger RNA (mRNA… CONTINUE READING
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

  • B Marcheva, KM Ramsey, ED Buhr
  • Nature
  • 2010
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