Regulation of contact allergy in the B cell--deficient mouse.


We have examined the obligate role of B cells in the regulation of allergic contact dermatitis. Our model is ACD in mice made B cell deficient by the chronic administration from birth of a goat antisera to mouse IgM. The following ACD phenomena are well demonstrated in these mice: (1) acquisition and expression of ACD, (2) spontaneous waning of ACD soon… (More)


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