Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region

@article{Han2003RegulationOC,
  title={Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region},
  author={Baoguang Han and Zizheng Dong and Yang Liu and Qun Chen and Katsuyuki Hashimoto and Jian-Ting Zhang},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={5325-5337}
}
PTEN tumor suppressor serves as a major negative regulator of survival signaling mediated by PI3 kinase/AKT/protein kinase B pathway, and is inactivated in various human tumors. Elucidation of mechanisms responsible for PTEN expression is important for providing insight into strategies to control the loss of PTEN expression in human cancers. Although recent studies suggested that p53 and Egr-1 can modulate induced PTEN expression, the mechanism responsible for ubiquitous constitutive expression… CONTINUE READING