Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate

  title={Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate},
  author={Leonie van Zeijl and Bas Ponsioen and Ben N G Giepmans and Aafke Ariaens and Friso R. Postma and P{\'e}ter V{\'a}rnai and Tamas Balla and Nullin Divecha and Kees Jalink and Wouter H Moolenaar},
  journal={The Journal of Cell Biology},
  pages={881 - 891}
Cell-cell communication through connexin43 (Cx43)-based gap junction channels is rapidly inhibited upon activation of various G protein-coupled receptors; however, the mechanism is unknown. We show that Cx43-based cell-cell communication is inhibited by depletion of phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) from the plasma membrane. Knockdown of phospholipase Cbeta3 (PLCbeta3) inhibits PtdIns(4,5)P(2) hydrolysis and keeps Cx43 channels open after receptor activation. Using a… CONTINUE READING


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Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels

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Acute downregulation of connexin 43 at wound sites leads to a reduced infl am - matory response , enhanced keratinocyte proliferation and wound fi bro - blast migration

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