Regulation of connexin-43, GFAP, and FGF-2 is not accompanied by changes in astroglial coupling in MPTP-lesioned, FGF-2-treated parkinsonian mice.

@article{Rufer1996RegulationOC,
  title={Regulation of connexin-43, GFAP, and FGF-2 is not accompanied by changes in astroglial coupling in MPTP-lesioned, FGF-2-treated parkinsonian mice.},
  author={M Rufer and S. Dashkovskiy B. R{\"u}ffer F. Wirth and Andreas Hofer and Rolf Dermietzel and Alfredo Pastor and Helmut Kettenmann and Klaus Unsicker},
  journal={Journal of neuroscience research},
  year={1996},
  volume={46 5},
  pages={606-17}
}
Basic fibroblast growth factor (bFGF; FGF-2) has potent trophic effects on developing and toxically impaired midbrain dopaminergic (DAergic) neurons which are crucially affected in Parkinson's disease. The trophic effects of FGF-2 are largely indirect, both in vitro and in vivo, and possibly involve intermediate actions of astrocytes and other glial cells. To further investigate the cellular and molecular mechanisms underlying the restorative actions of FGF-2, and to analyse in more detail the… CONTINUE READING