Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins).

@article{GoppeltStruebe2001RegulationOC,
  title={Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins).},
  author={Margarete Goppelt-Struebe and Angelika Hahn and Dominika Iwanciw and Margot Rehm and Bernhard Banas},
  journal={Molecular pathology : MP},
  year={2001},
  volume={54 3},
  pages={176-9}
}
AIM Connective tissue growth factor (ccn; ctgf) gene expression is upregulated in fibrotic renal glomeruli. Therefore, the regulation and pharmacological modulation of ccn2 (ctgf) mRNA expression was investigated in a human renal mesangial cell line. METHODS A human renal mesangial cell line was cultured in vitro under standard conditions. After stimulation, RNA was extracted and ccn2 (ctgf) mRNA expression assessed by northern blot analysis. RESULTS The expression of ccn2 (ctgf) mRNA was… CONTINUE READING

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