Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor alpha.

@article{Weiner1989RegulationOC,
  title={Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor alpha.},
  author={Francis R. Weiner and Amy G. Shah and Paul J. Smith and Charles S. Rubin and Mark A. Zern},
  journal={Biochemistry},
  year={1989},
  volume={28 9},
  pages={4094-9}
}
An early feature in the development of adipocytes from fibroblast-like precursor cells is the biogenesis of an extracellular basement membrane (Napolitano, 1963; Kuri-Harcuch et al., 1984). Interactions between components of the basement membrane (e.g., collagens) and the surfaces of differentiating adipocytes are thought to regulate subsequent phases of the developmental program. Since fibroblasts principally secrete type I and III collagens whereas type IV collagen is abundant in basement… CONTINUE READING
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