Regulation of collagen alpha1(I) expression in hepatic stellate cells.

@article{Lindquist2000RegulationOC,
  title={Regulation of collagen alpha1(I) expression in hepatic stellate cells.},
  author={Jeffrey N Lindquist and Branko Stefanovic and David Brenner},
  journal={Journal of gastroenterology},
  year={2000},
  volume={35 Suppl 12},
  pages={80-3}
}
The regulation of collagen alpha1(I) expression in hepatic stellate cells (HSCs) occurs in a complex fashion that is just beginning to be determined. The presence of regulatory sequences in both the 5' and 3' regions of the mRNA appear to be critical to its regulation in HSCs and are involved in the increased expression of collagen in activated HSCs. The 3' UTR contains a C-rich site that binds alphaCP, a known RNA-binding protein that is responsible for the increased stability of the mRNA in… CONTINUE READING

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