Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.

@article{Xu1998RegulationOC,
  title={Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.},
  author={Guorong Xu and Gerald Salen and Sarah Shefer and G. Stephen Tint and L. B. Nguyen and Tassy Parker and Theresa S. Chen and Jay W. Roberts and Xiaomu Kong and David Greenblatt},
  journal={Journal of lipid research},
  year={1998},
  volume={39 8},
  pages={1608-15}
}
The effect of cholesterol feeding (3 g/day) on bile acid synthesis was examined in 10 New Zealand white rabbits (NZW), 8 Watanabe heterozygous and 10 homozygous rabbits with partial and complete deficiencies of LDL receptors. After 10 days of cholesterol feeding, bile fistulas were constructed and bile acid pool sizes were measured. Cholesterol feeding increased plasma and hepatic cholesterol levels in all rabbit groups. Baseline bile acid pool sizes were smaller (P < 0.01) in heterozygotes… CONTINUE READING