Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.

@article{Robbins2012RegulationOC,
  title={Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.},
  author={G. Robbins and Agnieszka Dorota Truax and Beckley K Davis and Lu Zhang and Willie June Brickey and Jenny P-Y Ting},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 29},
  pages={24294-303}
}
Most of the nucleotide-binding domain, leucine-rich repeat (NLR) proteins regulate responses to microbial and damage-associated products. Class II transactivator (CIITA) has a distinct function as the master regulator of class II major histocompatibility complex (MHC-II) transcription. Recently, human NLRC5 was found to regulate MHC-I in cell lines; however, a host of conflicting positive and negative functions has been attributed to this protein. To address the function of NLRC5 in a… CONTINUE READING
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