Regulation of citric acid cycle by calcium.

  title={Regulation of citric acid cycle by calcium.},
  author={B. H. Wan and Kathryn F Lanoue and Joseph Y Cheung and Russell C. Scaduto},
  journal={The Journal of biological chemistry},
  volume={264 23},
The relationship of extramitochondrial Ca2+ to intramitochondrial Ca2+ and the influence of intramitochondrial free Ca2+ concentrations on various steps of the citric acid cycle were evaluated. Ca2+ was measured using the Ca2+ sensitive fluorescent dye fura-2 trapped inside the rat heart mitochondria. The rate of utilization of specific substrates and the rate of accumulation of citric acid cycle intermediates were measured at matrix free Ca2+ ranging from 0 to 1.2 microM. A change in matrix… CONTINUE READING


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