Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators.

@article{Kornmann2007RegulationOC,
  title={Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators.},
  author={Beno{\^i}t Kornmann and Olivier Schaad and H. -D. Reinke and Camille Saini and Ueli Schibler},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2007},
  volume={72},
  pages={
          319-30
        }
}
The mammalian circadian timing system has a hierarchical structure, in that a master pacemaker located in the suprachiasmatic nuclei (SCN) coordinates slave oscillators present in virtually all body cells. In both the SCN and peripheral organs, the rhythm-generating oscillators are self-sustained and cell-autonomous, and it is likely that the molecular makeup of master and slave oscillators is nearly identical. However, due to variations in period length, the phase coherence between peripheral… CONTINUE READING
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