Regulation of ciliary adenylate cyclase by Ca2+ in Paramecium.

  title={Regulation of ciliary adenylate cyclase by Ca2+ in Paramecium.},
  author={Michael Gustin and David L. G. Nelson},
  journal={The Biochemical journal},
  volume={246 2},
In the ciliated protozoan Paramecium, Ca2+ and cyclic nucleotides are believed to act as second messengers in the regulation of the ciliary beat. Ciliary adenylate cyclase was activated 20-30-fold (half-maximal at 0.8 microM) and inhibited by higher concentrations (10-20 microM) of free Ca2+ ion. Ca2+ activation was the result of an increase in Vmax., not a change in Km for ATP. The activation by Ca2+ was seen only with Mg2+ATP as substrate; with Mn2+ATP the basal adenylate cyclase activity was… CONTINUE READING


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