Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.

  title={Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.},
  author={Antoine E. Roux and Aur{\'e}lie Quissac and Pascal Chartrand and Gerardo Ferbeyre and Luis A. Rokeach},
  journal={Aging cell},
  volume={5 4},
Budding yeast shows a progressive decline in viability after entering stationary phase, a phenomenon known as chronological aging. We show here that the fission yeast Schizosaccharomyces pombe also undergoes chronological aging and that the process is regulated by genes controlling two related nutrient signalling pathways. The first pathway includes the serine/threonine cAMP-activated protein kinase Pka1 and the second pathway comprises the serine/threonine kinase Sck2, a homologue of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 39 extracted citations

A novel gene, ecl1(+), extends the chronological lifespan in fission yeast.

FEMS yeast research • 2008
View 14 Excerpts
Highly Influenced

Programmed cell death in fission yeast Schizosaccharomyces pombe.

Biochimica et biophysica acta • 2008
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 56 references

Global transcriptional responses of fission yeast to environmental stress.

Molecular biology of the cell • 2003
View 3 Excerpts
Highly Influenced

The Ras and Sch9 pathways regulate stress resistance and longevity

Experimental Gerontology • 2003
View 9 Excerpts
Highly Influenced

Pka1 and Sck2 control longevity

S. pombe, A. E. Roux
The Authors Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland • 2006

Similar Papers

Loading similar papers…