Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.

@article{Roux2006RegulationOC,
  title={Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.},
  author={Antoine E. Roux and Aur{\'e}lie Quissac and Pascal Chartrand and Gerardo Ferbeyre and Luis A. Rokeach},
  journal={Aging cell},
  year={2006},
  volume={5 4},
  pages={345-57}
}
Budding yeast shows a progressive decline in viability after entering stationary phase, a phenomenon known as chronological aging. We show here that the fission yeast Schizosaccharomyces pombe also undergoes chronological aging and that the process is regulated by genes controlling two related nutrient signalling pathways. The first pathway includes the serine/threonine cAMP-activated protein kinase Pka1 and the second pathway comprises the serine/threonine kinase Sck2, a homologue of… CONTINUE READING

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The Authors Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland • 2006

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