Regulation of chromatin structure by site-specific histone H3 methyltransferases

  title={Regulation of chromatin structure by site-specific histone H3 methyltransferases},
  author={Stephen C. Rea and F. Eisenhaber and D. O'Carroll and B. Strahl and Z. Sun and M. Schmid and S. Opravil and K. Mechtler and C. Ponting and C. Allis and T. Jenuwein},
  • Stephen C. Rea, F. Eisenhaber, +8 authors T. Jenuwein
  • Published 2000
  • Biology, Medicine
  • Nature
  • The organization of chromatin into higher-order structures influences chromosome function and epigenetic gene regulation. [...] Key Result We mapped the catalytic motif to the evolutionarily conserved SET domain, which requires adjacent cysteine-rich regions to confer histone methyltransferase activity. Methylation of lysine 9 interferes with phosphorylation of serine 10, but is also influenced by pre-existing modifications in the amino terminus of H3.Expand Abstract
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