Regulation of cholinergic development by target contact.

  title={Regulation of cholinergic development by target contact.},
  author={Jeremy B. Tuttle},
  journal={Federation proceedings},
  volume={44 12},
Avian ciliary ganglion neurons in cell culture have been used as a model neuronal system to examine the developmental role of direct contact with an appropriate target tissue. Live myotubes, which are immediately innervated, and their membrane remnants, on which neurons form terminal structures, were both found to stimulate or accelerate the acquisition or retention of important parameters of neuronal function. Contact with the target membrane supports survival, aids retention of active… CONTINUE READING