Regulation of cholecystokinin secretion by bombesin in STC-1 cells.

  title={Regulation of cholecystokinin secretion by bombesin in STC-1 cells.},
  author={Norah Snow and Vera Prpic and Allen W. Mangel and Ala I. Sharara and Douglas C McVey and Lyn Hurst and Steven R Vigna and Rodger A. Liddle},
  journal={The American journal of physiology},
  volume={267 5 Pt 1},
Bombesin stimulates cholecystokinin (CCK) secretion, presumably by a direct effect on the intestinal CCK cell. The present objectives were to characterize bombesin-stimulated CCK release and to investigate the role of calcium in CCK secretion in an intestinal CCK-producing cell line (STC-1). Bombesin caused a dose-dependent release of CCK, which was reduced either in the absence of extracellular calcium or by calcium channel blockade, suggesting that influx of calcium is necessary for CCK… CONTINUE READING

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